From lamins to lamina: a structural perspective
نویسندگان
چکیده
منابع مشابه
Altering lamina assembly reveals lamina-dependent and -independent functions for A-type lamins.
Lamins are intermediate filament proteins that form a fibrous meshwork, called the nuclear lamina, between the inner nuclear membrane and peripheral heterochromatin of metazoan cells. The assembly and incorporation of lamin A/C into the lamina, as well as their various functions, are still not well understood. Here, we employed designed ankyrin repeat proteins (DARPins) as new experimental tool...
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Systematic correlation of phenotype with genotype is a key goal of the emerging field of phenomics, which is expected to help define complex diseases. Careful evaluation of phenotype-genotype associations in monogenic disorders, such as laminopathies, might provide new hypotheses to be tested with molecular and cellular studies and might also suggest potential new intervention strategies. For i...
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ژورنال
عنوان ژورنال: Histochemistry and Cell Biology
سال: 2013
ISSN: 0948-6143,1432-119X
DOI: 10.1007/s00418-013-1104-y